College of Veterinary Medicine
Vite Lab
Led by Charles Vite · Small Animal Clinical Sciences
What we study
The Vite Lab studies neurodegenerative diseases using naturally occurring large-animal models of human disease, such as cats with Niemann-Pick type C1 disease. It develops and tests gene therapy and drug treatments and ways to measure disease severity.
What working here is like
- Wet lab
- Projects
- 2
- Papers
- 5
Current projects
Support of the NPC1 cat colony for future preclinical trials
Maintaining a colony of cats with NPC1 disease for testing new treatments.
AAV-mediated gene therapy for CNS disease correction in feline NPC1 disease
Tests AAV gene therapy in cats with NPC1 disease, a fatal neurodegenerative disorder, to see whether it can correct disease in the central nervous system.
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- Clinical response to systemic AAV gene therapy in a large animal model of late-stage lysosomal storage disease
2026 · Gene Therapy
Tests whether early gene therapy can correct brain damage in a feline model of alpha-mannosidosis.
- Diagnosis and therapy of Niemann-Pick disease type C1- what have we learned that can help veterinary patients?
2026 · Rare Disease and Orphan Drugs Journal
Discusses translating findings from feline Niemann-Pick disease to human and veterinary medicine.
Show 3 more papersShow fewer
- Effect of disease progression on CSF-directed AAV gene therapy in a large brain animal model of lysosomal storage disease
2025 · Molecular Therapy — Methods & Clinical Development
Tests whether gene therapy can correct brain damage at different disease stages in a feline model.
- Adeno-associated vector corneal gene therapy reverses corneal clouding in a feline model of mucopolysaccharidosis VI
2025 · PLoS ONE
Shows that gene therapy can clear corneal clouding in a feline model of mucopolysaccharidosis VI.
- Intracisternal vs intraventricular injection of AAV1 result in comparable, widespread transduction of the dog brain
2024 · Gene Therapy
Compares two methods of delivering gene therapy to the brain in dogs.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
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