College of Medicine
Scindia Lab
Led by Yogesh Scindia · Medicine
What we study
The Scindia Lab studies how iron and ferroptosis (a type of cell death) affect diseases like lupus and fungal infections. They use experiments to find new treatments for these conditions.
What working here is like
- Wet lab
- Mice
- Coding helps
- Projects
- 3
- Papers
- 5
Current projects
Targeting ferroptosis in renal tubular epithelial cells to improve outcomes of lupus nephritis
Tests whether blocking ferroptosis, a type of iron-driven cell death, in kidney tube cells can reduce kidney damage in lupus nephritis.
Project Functional role of iron in T follicular helper cell development
The lab studies how iron affects a type of immune cell that helps B cells make antibodies in lupus. Students compare gene activity and iron levels in these cells from normal and lupus mice, and test how removing iron changes cell signaling and function.
From the Spring 2025 UF Undergraduate Research Symposium · abstract book, p. 461
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Essential Role of Hepcidin in Host Resistance to Disseminated Candidiasis
Mice that could not make the hormone hepcidin had more fungal growth and kidney damage when infected with Candida. Giving them a hepcidin‑like drug reduced the infection, showing the hormone protects against fungal disease.
From the Spring 2025 UF Undergraduate Research Symposium · abstract book, p. 80
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- Vamifeport, a clinical stage oral ferroportin inhibitor, alleviates murine lupus nephritis: A pilot study
2026 · Clinical Immunology
- Iron metabolism and ferroptosis: druggable targets to delay the progression of lupus nephritis
2025 · American Journal of Physiology-Renal Physiology
Finds iron and cell death may worsen lupus kidney damage.
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- Essential role of hepcidin in host resistance to disseminated candidiasis
2025 · Cell Reports
Shows hepcidin helps fight fungal infections in sick livers.
- Myeloid heme oxygenase-1 deficiency exacerbates TLR7-induced lupus 2136
2025 · The Journal of Immunology
Shows low HO-1 in lupus mice worsens immune responses.
- Alpha-1 antitrypsin modulates neutrophil phenotype and function: implications for inflammatory regulation
2025 · Journal of Leukocyte Biology
Finds protein alpha-1 antitrypsin helps control inflammation.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
Yogesh Scindia hasn't set up this page yet. Their UF Scholars profile lists their publications.