College of Medicine
Zolotukhin Lab
Led by Sergei Zolotukhin · Pediatrics
What we study
The lab studies gene therapy using engineered viruses like AAV (adenovirus-associated virus) to deliver genes to specific tissues in the body. They focus on improving virus targeting and large-scale production for medical applications.
What working here is like
- Wet lab
- Project
- 1
- Papers
- 5
Current projects
A Novel Gene Therapy to Target Glioblastoma via Custom-Engineered Adenovirus-Associated Viral Vectors
Developing specialized AAV vectors to treat glioblastoma, a type of brain cancer.
Summaries are written by AI in plain language from public symposium abstracts and may be imperfect.
Recent papers, explained
- Biodistribution and safety of a single rAAV3B-AAT vector for silencing and replacement of alpha-1 antitrypsin in Cynomolgus macaques
2024 · Molecular Therapy — Methods & Clinical Development
Tests a dual-function AAV vector for treating alpha-1 antitrypsin deficiency in monkeys.
- Suspension Culture Production and Purification of Adeno-Associated Virus by Iodixanol Density Gradient Centrifugation for In Vivo Applications
2024 · Journal of Visualized Experiments
Describes making and purifying AAV vectors using a density gradient method.
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- Exploring the Comprehensive Kozak Sequence Landscape for AAV Production in Sf9 System
2023 · Viruses
Explores how gene sequences affect AAV production in insect cells.
- Intravitreal injection of a rationally designed AAV capsid library in non-human primate identifies variants with enhanced retinal transduction and neutralizing antibody evasion
2023 · Molecular Therapy
Creates improved AAV capsids for retinal gene therapy in monkeys.
- Rational Design of AAV-rh74, AAV3B, and AAV8 with Limited Liver Targeting
2023 · Viruses
Designs AAV capsids that avoid liver targeting when injected.
Plain-language summaries are AI-written and reviewed by us; check the paper for details.
How to reach out
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